CD61
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[1] CD61 is a cluster of differentiation found on thrombocytes.
Contents
Structure and function
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[2]
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[3]
Interactions
CD61 has been shown to interact with PTK2,[4][5] ITGB3BP,[6][7] TLN1[8][9] and CIB1.[10]
See also
References
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Further reading
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External links
- CD61 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGB3 Info with links in the Cell Migration Gateway
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