CGS-12066A

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
CGS-12066A
CGS-12066A.svg
Systematic (IUPAC) name
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
Identifiers
CAS Number 109028-10-6 YesY
PubChem CID: 2689
IUPHAR/BPS 109
ChemSpider 2588 N
Chemical data
Formula C17H17F3N4
Molecular mass 334.338 g/mol
  • C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24
  • InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3 N
  • Key:LXFHSCDLMBZYKY-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.[1][2] It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.[3][4]

References

  1. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004 Aug;370(2):114-23. doi:10.1007/s00210-004-0951-4 PMID 15322733
  2. Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Research. 15 March 2005;1038(1):118-21. PMID 15748881
  3. Monti JM, Jantos H. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Progress in Brain Research. 2008;172:625-46. PMID 18772053
  4. Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 20 January 2010;165(2):561-8. PMID 19837141


<templatestyles src="Asbox/styles.css"></templatestyles>