CGS-15943
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
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Clinical data | |
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Identifiers | |
CAS Number | 104615-18-1 |
ATC code | none |
PubChem | CID: 2690 |
IUPHAR/BPS | 384 |
ChemSpider | 2589 |
ChEBI | CHEBI:131351 |
ChEMBL | CHEMBL16687 |
Chemical data | |
Formula | C13H8ClN5O |
Molecular mass | 285.689 g/mol |
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CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline.[1][2] Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.[3][4][5][6][7]
See also
References
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs not assigned an ATC code
- Adenosine receptor antagonists
- Cardiovascular system drug stubs
- Nervous system drug stubs