Calcium carbimide

Calcium carbimide

File:Citrated calcium carbimide.png
Systematic (IUPAC) name
calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	8013-88-5 Y
ATC code	N07BB02 (WHO)
PubChem	CID: 6335910
ChemSpider	21106422 Y
UNII	ZLR270912W N
ChEMBL	CHEMBL2106095 N
Chemical data
Formula	C6H8O7.CH2N2.Ca
Molecular mass	288.268 g/mol
SMILES [Ca+2].O=C([O-])CC(O)(CC(=O)O)C([O-])=O.N#CNC
InChI InChI=1S/C6H8O7.C2H4N2.Ca/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-4-2-3;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);4H,1H3;/q;;+2/p-2 Y Key:ZZOBQLACMMNMCT-UHFFFAOYSA-L Y
NY (what is this?)  (verify)

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

A recent 9-year study found that incorporation of supervised carbimide and the similar drug, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.

Temposil was developed by Drs. Ken Ferguson and Gordon Bell, who tested the drug on themselves. It was patented in 1955 by the Alcoholism Research Foundation of Ontario.

See also

• Acamprosate