Caramboxin

Caramboxin

Names
IUPAC name 2-Carboxy-3-hydroxy-5-methoxyphenylalanine
Identifiers
ChemSpider	32779488
Jmol 3D model	Interactive image
InChI InChI=1S/C11H13NO6/c1-18-6-2-5(3-7(12)10(14)15)9(11(16)17)8(13)4-6/h2,4,7,13H,3,12H2,1H3,(H,14,15)(H,16,17) Key: DYJIDGJHOLTGBO-UHFFFAOYSA-N InChI=1/C11H13NO6/c1-18-6-2-5(3-7(12)10(14)15)9(11(16)17)8(13)4-6/h2,4,7,13H,3,12H2,1H3,(H,14,15)(H,16,17) Key: DYJIDGJHOLTGBO-UHFFFAOYAB
SMILES COc1cc(c(c(c1)O)C(=O)O)CC(C(=O)O)N
Properties
Chemical formula	C11H13NO6
Molar mass	255.23 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Caramboxin (CBX) is a toxin found in star fruit (Averrhoa carambola)). Individuals with some types of kidney disease are susceptible to adverse neurological effects including intoxication, seizures and even death after eating star fruit. Caramboxin has been identified as the neurotoxin responsible for these effects. Caramboxin is a non-proteinogenic amino acid that stimulates the glutamate receptors in neurons. Its chemical structure is similar to the amino acid phenylalanine. Caramboxin is an agonist of both NMDA and AMPA glutamatergic ionotropic receptors with potent excitatory, convulsant, and neurodegenerative properties.