Cation channels of sperm
From Infogalactic: the planetary knowledge core
| cation channel, sperm associated 1 | |
|---|---|
| Identifiers | |
| Symbol | CATSPER1 |
| IUPHAR | 388 |
| Entrez | 117144 |
| HUGO | 17116 |
| OMIM | 606389 |
| RefSeq | NM_053054 |
| UniProt | Q8NEC5 |
| Other data | |
| Locus | Chr. 11 q12.1 |
| cation channel, sperm associated 2 | |
|---|---|
| Identifiers | |
| Symbol | CATSPER2 |
| IUPHAR | 389 |
| Entrez | 117155 |
| HUGO | 18810 |
| OMIM | 607249 |
| RefSeq | NM_172097 |
| UniProt | Q96P55 |
| Other data | |
| Locus | Chr. 15 q13-q15 |
| cation channel, sperm associated 3 | |
|---|---|
| Identifiers | |
| Symbol | CATSPER3 |
| IUPHAR | 390 |
| Entrez | 347732 |
| HUGO | 20819 |
| OMIM | 609120 |
| RefSeq | NM_178019 |
| UniProt | Q86XQ3 |
| Other data | |
| Locus | Chr. 5 q31.2 |
| cation channel, sperm associated 4 | |
|---|---|
| Identifiers | |
| Symbol | CATSPER4 |
| IUPHAR | 391 |
| Entrez | 378807 |
| HUGO | 23220 |
| OMIM | 609121 |
| RefSeq | NM_198137 |
| UniProt | Q7RTX7 |
| Other data | |
| Locus | Chr. 1 p35.3 |
The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization.[1] The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
- CATSPER1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GeneReviews/NCBI/NIH/UW entry on CATSPER-Related Male Infertility
- Lua error in package.lua at line 80: module 'strict' not found.
