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In Aztec mythology, the Centzonuitznahua Nahuatl pronunciation: [sent͡sonwiːtsˈnaːwa] (or, in plural, Centzon Huitznauhtin Nahuatl pronunciation: [sent͡sonwiːtsˈnaːwtin]) were the gods of the southern stars. They are the evil elder sons of Coatlicue, and their sister is Coyolxauhqui. They and their sister tried to murder their mother upon learning of her pregnancy with Huitzilopochtli; their plan was thwarted when their brother sprang from the womb—fully grown and garbed for battle—and killed them all.

The Centzonhuitznaua are known as the "Four Hundred Southerners"; the gods of the northern stars are the Centzonmimixcoa.