Chromosome 14 (human)

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Chromosome 14 (human)
Human male karyotpe high resolution - Chromosome 14 cropped.png
Pair of human chromosome 14 (after G-banding).
One is from mother, one is from father.
Human male karyotpe high resolution - Chromosome 14.png
Chromosome 14 pair in human male karyogram.
Features
Length (bp) 107,043,718 bp
Number of genes 1,655
Type Autosome
Centromere position Acrocentric[1]
Identifiers
RefSeq NC_000014
GenBank CM000676
Map of Chromosome 14
Ideogram of human chromosome 14. Mbp means mega base pair. See locus for other notation.

Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 107 million base pairs (the building material of DNA) and represents between 3 and 3.5% of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 14 likely contains between 700 and 1,300 genes.

The centromere of chromosome 14 is positioned approximately at position 19.0-19.1 Mbp.

Genes

The following are some of the genes located on chromosome 14:

  • ATXN3: Ataxin-3 (Machado-Joseph disease)
  • COCH: coagulation factor C homolog, cochlin (Limulus polyphemus)
  • GALC: galactosylceramidase (Krabbe disease)
  • GCH1: GTP cyclohydrolase 1 (dopa-responsive dystonia)
  • IGH@: immunoglobulin heavy chain locus
  • IFT43: intraflagellar transport 43
  • MYH7: myosin heavy chain beta (MHC-β) isoform[2]
  • NPC2: Niemann-Pick disease, type C2
  • PSEN1: presenilin 1 (Alzheimer disease 3)
  • SERPINA1: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
  • TSHR: thyroid stimulating hormone receptor
  • FAM71D: Family With Sequence Similarity 71, Member D

Diseases & disorders

The following diseases are some of those related to genes on chromosome 14:

References

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