Clonitazene

Clonitazene

Systematic (IUPAC) name
2-[2-[(4-chlorophenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
Clinical data
Legal status	CA: Schedule I DE: Anlage I (Controlled) US: Schedule I
Identifiers
CAS Number	3861-76-5
ATC code	none
PubChem	CID: 62528
DrugBank	DB01523 Y
ChemSpider	56301 Y
UNII	S90R21A2V2 Y
ChEMBL	CHEMBL2104616
Synonyms	Clonitazene
Chemical data
Formula	C20H23ClN4O2
Molecular mass	386.88 g/mol
SMILES [O-] [N+](=O)c3ccc1c(nc(n1CCN(CC)CC)Cc2ccc(Cl)cc2)c3
InChI InChI=1S/C20H23ClN4O2/c1-3-23(4-2)11-12-24-19-10-9-17(25(26)27)14-18(19)22-20(24)13-15-5-7-16(21)8-6-15/h5-10,14H,3-4,11-13H2,1-2H3 Y Key:GPZLDQAEBHTMPG-UHFFFAOYSA-N Y
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Clonitazene is an opioid analgesic of approximately three times the potency of morphine. It is related to etonitazene, an opioid of significantly higher potency. Clonitazene is not currently marketed. It is a controlled substance; in the United States it is a Schedule I Narcotic controlled substance with a DEA ACSCN of 9612 and an annual manufacturing quota of zero.

Synthesis

File:Clonitrazine synthesis.svg

Clonitrazine synthesis: Hoffmann et al., U.S. Patent 2,935,514 (1960 to Ciba).