Clostridium sporogenes
| Clostridium sporogenes | |
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| Clostridium botulinum stained with gentian violet. | |
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C. sporogenes
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| Binomial name | |
| Clostridium sporogenes (Metchnikoff 1908) Bergey et al. 1923[1]
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Clostridium sporogenes is a species of Gram-positive bacteria that belongs to the genus Clostridium. Like other strains of Clostridium, it is an anaerobic, rod-shaped bacterium that produces oval, subterminal endospores and is commonly found in soil. Unlike Clostridium botulinum, it does not produce the botulinum neurotoxins. In colonized hosts, it serves a symbiotic rather than pathogenic role.
In the human microbiome, C. sporogenes serves as a symbiotic bacteria that uses tryptophan to synthesize indole and then subsequently 3-indolepropionic acid (IPA)[2] – a type of auxin (plant hormone)[3][4] – which serves as an incredibly potent antioxidant within the human body and brain.[2][5][6] IPA is an even more potent scavenger of hydroxyl radicals than melatonin.[5][6] Similar to melatonin but unlike other antioxidants, it scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds.[5][6][7] C. sporogenes is the only bacteria known to synthesize 3-indolepropionic acid in vivo at levels which are subsequently detectable in the blood stream of the host.[2][8]
It is being investigated as a way to deliver cancer-treating drugs to tumours in patients.[9] C. sporogenes is often used as a surrogate for C. botulinum when testing the efficacy of commercial sterilisation.[10]
References
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- ↑ BBC News "Soil bacterium helps kill cancers."
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
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