Steroid-induced osteoporosis
Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone (7.5 mg of prednisolone), especially when this is in excess of three months.[1][2] The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases.[3] Alternate day use may not prevent this complication.[4]
Mechanisms of SIOP include:[5]
- Direct inhibition of osteoblast function
- Direct enhancement of bone resorption
- Inhibition of gastrointestinal calcium absorption
- Increased urine calcium loss
- Inhibition of sex steroids
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Cochrane Reviews. [url=http://summaries.cochrane.org/CD000952/calcium-and-vitamin-d-for-treating-osteoporosis-caused-by-the-use-of-steroids "Calcium and vitamin D for treating osteoporosis caused by the use of steroids"]
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Steroid-induced osteoporosis By Susan Ott, MD. Updated January 28, 2009. Retrieved on 26 March 2009
