Cysteine dioxygenase
From Infogalactic: the planetary knowledge core
| Cysteine dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.11.20 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
|||||||||
| cysteine dioxygenase, type I | |
|---|---|
| Identifiers | |
| Symbol | CDO1 |
| Entrez | 1036 |
| HUGO | 1795 |
| OMIM | 603943 |
| RefSeq | NM_001801 |
| UniProt | Q16878 |
| Other data | |
| EC number | 1.13.11.20 |
| Locus | Chr. 5 q23.2 |
Cysteine dioxygenase (CDO, CAS number: 37256-59-0) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.
File:Cysteine-dioxygenase-reaction.png
CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation
Cysteine sulfinic acid lies at a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.
References
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External links
- CDO1 human gene location in the UCSC Genome Browser.
- CDO1 human gene details in the UCSC Genome Browser.
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