Diacylglycerol lipase
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diacylglycerol lipase, alpha | |
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Identifiers | |
Symbol | DAGLA |
Alt. symbols | C11orf11 |
Entrez | 747 |
HUGO | 1165 |
RefSeq | NM_006133 |
UniProt | Q9Y4D2 |
Other data | |
EC number | 3.1.1.- |
Locus | Chr. 11 q12.3 |
diacylglycerol lipase, beta | |
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Identifiers | |
Symbol | DAGLB |
Entrez | 221955 |
HUGO | 28923 |
RefSeq | NM_139179 |
UniProt | Q8NCG7 |
Other data | |
EC number | 3.1.1.- |
Locus | Chr. 7 p22.1 |
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
Inhibitors
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
- Diacylglycerol Lipase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.34
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Prostanoid signaling
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See also: Leukotrienergics
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Leukotriene signaling
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Receptor (ligands) |
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Enzyme (inhibitors) |
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See also: Prostanoids
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