Diphenadione
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Structural formula of diphenadione | |
Ball-and-stick model of the diphenadione molecule | |
Names | |
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IUPAC name
2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
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Other names
Diphacinone; Diphenandione
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Identifiers | |
82-66-6 ![]() |
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ChEMBL | ChEMBL1413199 |
ChemSpider | 6463 |
Jmol 3D model | Interactive image |
KEGG | D07136 ![]() |
PubChem | 6719 |
UNII | 54CA01C6JX ![]() |
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Properties | |
C23H16O3 | |
Molar mass | 340.38 g·mol−1 |
Pharmacology | |
ATC code | B01 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Diphenadione is a vitamin K antagonist that has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents.[citation needed] The chemical compound is an anti-coagulant with active half-life[verification needed] longer than warfarin and other synthetic indandione anticoagulants.[1][better source needed]
It is toxic to mammals, in all forms, to all modes of contact, including via skin;[citation needed] exposure and oral ingestion of the toxin may cause irregular heartbeat and major maladies associated with its impact on blood clotting, depending on dose.[verification needed][2][better source needed] As a "second-generation" anticoagulant, diphenadione is more toxic than the first generation compounds (e.g., warfarin).[3]:436 For purposes of treating toxicity on exposure, diphenadione is grouped with other vitamin K antagonists (coumarins and indandiones); despite being directed at rodents and being judged as less hazardous to humans and domestic animals than other rodenticides in use (by the U.S. Environmental Protection Agency), indandione anticoagulants, nevertheless, "may cause human toxicity at a much lower dose than conventional 'first-generation anticoagulants'… and can bioaccumulate in the liver."[4]:173
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.[needs update]
- ↑ Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.[needs update]
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found. [p. 173, emphasis in source].
Further reading
- Lua error in package.lua at line 80: module 'strict' not found. An online pesticide database that gives more information about the safety issues associated with use of diphenadione.
- Lua error in package.lua at line 80: module 'strict' not found. A safety handbook that explains how incidents of poisoning by various rodenticides are treated.
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- Indandiones
- Vitamin K antagonists