Diphenylpyraline
Systematic (IUPAC) name | |
---|---|
4-benzhydryloxy-1-methyl-piperidine
|
|
Clinical data | |
AHFS/Drugs.com | International Drug Names |
Legal status |
|
Routes of administration |
Oral, Topical |
Pharmacokinetic data | |
Biological half-life | 24–40 hours[1] |
Identifiers | |
CAS Number | 147-20-6 Y |
ATC code | R06AA07 (WHO) |
PubChem | CID: 3103 |
IUPHAR/BPS | 7165 |
DrugBank | DB01146 Y |
ChemSpider | 2992 Y |
UNII | 33361OE3AV Y |
KEGG | D07862 Y |
ChEBI | CHEBI:59788 Y |
ChEMBL | CHEMBL1492 Y |
Synonyms | 4-(diphenylmethoxy)-1-methyl-piperidine |
Chemical data | |
Formula | C19H23NO |
Molecular mass | 281.392 g/mol |
|
|
|
|
(verify) |
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.[2][3][4] It is marketed in Europe for the treatment of allergies.[2][3][5] DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.[6] It has been shown to be useful in the treatment of Parkinsonism.[7]
Contents
Synthesis
Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine, is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.
Trade names
Arbid, Dafen, Dayfen, Histyn, Hispril, etc.
See also
<templatestyles src="Div col/styles.css"/>
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ H.K. Lawrence, R. Kapp, U.S. Patent 2,479,843 (1949).
- ↑ W.A. Schuler, DE 934890 (1951).
Aminoalkyl ethers |
|
||||||||
---|---|---|---|---|---|---|---|---|---|
Substituted alkylamines | |||||||||
Substituted ethylenediamines |
|
||||||||
Phenothiazine derivatives | |||||||||
Piperazine derivatives | |||||||||
Others for systemic use |
|
||||||||
For topical use | |||||||||
|
Dopaminergics |
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Anticholinergics | |||||||||||
Others | |||||||||||
|
|||||||||||
|
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
Receptor (ligands) |
|
||||||||
---|---|---|---|---|---|---|---|---|---|
Transporter (inhibitors) |
|
||||||||
Enzyme (inhibitors) |
|
||||||||
Others |
|
||||||||
|
<templatestyles src="Asbox/styles.css"></templatestyles>
This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it. |