Dopamine antagonist

Dopamine receptor antagonist Dopaminergic blockers
Drug class
Skeletal structor formula of Haloperidol, a typical antipsychotic
Class identifiers
Use	Schizophrenia, bipolar disorder, nausea and vomiting, etc.
ATC code	N05A
Biological target	Dopamine receptors
External links
MeSH	D012559

A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis. Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting.

Uses and examples

Clozapine, a second generation antipsychotic

Dopamine receptor antagonists are used for some diseases such as schizophrenia, bipolar disorder, nausea and vomiting. It can also control the symptoms of hypersexuality and increased orgasmic activity.

Antidopaminergics such as haloperidol can be an antidote for poisoning with cocaine, amphetamines and dopamine agonists such as bromocriptine and/or ropinirole.

• Agents such as atypical antipsychotics (coupled with serotonin antagonist effects): paliperidone, clozapine, risperidone, olanzapine, quetiapine, and ziprasidone
• Used as antiemetics: metoclopramide, droperidol, domperidone
• Used as tricyclic antidepressants: amoxapine, clomipramine, trimipramine
• Choline can antagonize dopamine directly or interfere with receptor function
• Melatonin suppresses dopamine activity as part of normal circadian rhythm functions, although pathological imbalances have been implicated in Parkinson's disease

Side effects

They may include one or more of the following and last indefinitely even after cessation of the dopamine antagonist, especially after long-term or high-dosage use:

• Dysphoria and depression
• Extrapyramidal symptoms, including:
  • Akathisia
  • Parkinsonism due to effects on the nigrostriatal pathway
  • Tardive dyskinesia (long-term use)
• Galactorrhea due to removal of dopamine-mediated inhibition (D2 receptor antagonism) on the lactotrophic cells in the anterior pituitary preventing the release of prolactin.
• Hyperprolactinaemia due to effects on the tuberoinfundibular pathway
• Increased appetite
• Irritability and aggression
• Low libido, sexual dysfunction and impotence due to blockage of the pleasure center (dopaminergic pathways)
• Menstrual disorder
• Metabolic changes with increased risk of obesity and diabetes mellitus type 2
• Neuroleptic Induced Deficit Syndrome (long-term use)
• Paranoia (rare)
• Sedation or psychomotor agitation
• Symptoms similar to ADHD
• Symptoms similar to narcolepsy

Examples

Examples of Dopamine antagonists include:

• acepromazine
• amisulpride
• amoxapine
• asenapine
• azaperone
• benperidol
• bromopride
• butaclamol
• clomipramine (mild)
• chlorpromazine
• chlorprothixene
• clopenthixol
• domperidone
• droperidol
• eticlopride
• flupenthixol
• fluphenazine
• fluspirilene
• haloperidol
• hydroxyzine
• iodobenzamide
• loxapine
• mesoridazine
• levomepromazine
• metoclopramide
• nafadotride
• nemonapride
• olanzapine
• paliperidone
• penfluridol
• perazine
• perphenazine
• pimozide
• prochlorperazine
• promazine
• quetiapine
• raclopride
• remoxipride
• risperidone
• spiperone
• spiroxatrine
• stepholidine
• sulpiride
• sultopride
• tetrahydropalmatine
• thiethylperazine
• thioridazine
• thiothixene
• tiapride
• trifluoperazine
• trifluperidol
• triflupromazine
• ziprasidone

See also

• Dopamine agonist
• Dopaminergic
• Serotonin antagonist
• Adrenergic antagonist
• Histamine antagonist
• Acetylcholine antagonist
• GABA antagonist

External links

• Dopamine antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)