Doramectin

Doramectin

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Systematic (IUPAC) name
(1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	Veterinary use only
Routes of administration	Injection, Topical and Oral
Identifiers
CAS Number	117704-25-3
ATCvet code	QP54AA03 (WHO)
PubChem	CID: 9832750
ChemSpider	8008478 Y
UNII	KGD7A54H5P Y
KEGG	D01129 Y
Chemical data
Formula	C50H74O14
Molecular mass	899.114
InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 Y Key:QLFZZSKTJWDQOS-YDBLARSUSA-N Y
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Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as an injection and as a 5 mg/ml topical solution.

Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health) in an 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.

Doramectin is also available for horses as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel. It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.