Doxofylline

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Doxofylline
Doxofylline.png
Doxofylline-3D-balls.png
Systematic (IUPAC) name
7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Identifiers
CAS Number 69975-86-6 YesY
ATC code R03DA11 (WHO)
PubChem CID: 50942
UNII MPM23GMO7Z YesY
KEGG D03898 YesY
Chemical data
Formula C11H14N4O4
Molecular mass 266.25 g/mol
  • CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
  (verify)

Doxofylline (INN, also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.[1]

It has antitussive[citation needed] and bronchodilator[2] effects, and acts as a phosphodiesterase inhibitor.[3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer side effects.[4]

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.[1]

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.


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