EGF module-containing mucin-like hormone receptor

egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
Symbol	EMR1
Alt. symbols	TM7LN3
IUPHAR	182
Entrez	2015
HUGO	3336
OMIM	600493
RefSeq	NM_001974
UniProt	Q14246
Other data
Locus	Chr. 19 p13.3

egf-like module containing, mucin-like, hormone receptor-like 2
Identifiers
Symbol	EMR2
IUPHAR	183
Entrez	30817
HUGO	3337
OMIM	606100
RefSeq	NM_152916
UniProt	Q9UHX3
Other data
Locus	Chr. 19 p13.1

egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
Symbol	EMR3
IUPHAR	184
Entrez	84658
HUGO	23647
OMIM	606101
RefSeq	NM_032571
UniProt	Q9BY15
Other data
Locus	Chr. 19 p13.1

egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
Symbol	EMR4P
Alt. symbols	GPR127
Entrez	326342
HUGO	19240
RefSeq	XM_940358
UniProt	Q86SQ3
Other data
Locus	Chr. 19 p13.3

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. There are four variants of EMR labeled 1-4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.

External links

• EMR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• EMR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• EMR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• EMR4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)