EMPA (drug)

EMPA
	File:EMPA.svg
Systematic (IUPAC) name
	N-Ethyl-N2-(6-methoxy-3-pyridinyl)-N2-[(2-methylphenyl)sulfonyl]-N-(3-pyridinylmethyl)glycinamide
Identifiers
CAS Number	680590-49-2
ATC code	none
PubChem	CID: 9981404
ChemSpider	8156996
Chemical data
Formula	C23H26N4O4S
Molecular mass	454.542 g/mol
	SMILES CCN(CC1=CN=CC=C1)C(=O)CN(C2=CN=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3C ;
	InChI InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3 ; Key:KJPHTXTWFHVJIG-UHFFFAOYSA-N ;

EMPA is a selective antagonist of the OX₂ receptor, with 900-fold selectivity in binding for OX₂ over OX₁.^[1]^[2]

References

↑ "Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists", [1], Pari Malherbe, Edilio Borroni, Emmanuel Pinard, Joseph G. Wettstein, and Frederic Knoflach, in Molecular Pharmacology, , 2009
↑ Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor. Br.J.Pharmacol. 156 1326. PMID 19751316.

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Systematic (IUPAC) name
File:EMPA.svg
N-Ethyl-N²-(6-methoxy-3-pyridinyl)-N²-[(2-methylphenyl)sulfonyl]-N-(3-pyridinylmethyl)glycinamide
Identifiers
CAS Number	680590-49-2
ATC code	none
PubChem	CID: 9981404
ChemSpider	8156996
Chemical data
Formula	C₂₃H₂₆N₄O₄S
Molecular mass	454.542 g/mol
SMILES CCN(CC1=CN=CC=C1)C(=O)CN(C2=CN=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3C
InChI InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3 Key:KJPHTXTWFHVJIG-UHFFFAOYSA-N