Elafin

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.[1][2][3]

Function

This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[3]

Clinical significance

Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.[4]

Elafin plays some role in gut inflammation. [5]

References

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  3. 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
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  5. http://articles.latimes.com/2012/nov/01/news/la-heb-engineered-bacteria-crohns-and-colitis-20121031

Further reading

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