Pregnanolone

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Pregnanolone
Eltanolone.svg
Names
IUPAC name
(3α,5β)-3-Hydroxypregnan-20-one
Identifiers
128-20-1
ChEBI CHEBI:1712 YesY
ChEMBL ChEMBL210952
ChemSpider 29132
Jmol 3D model Interactive image
PubChem 31402
Properties
C21H34O2
Molar mass 318.50 g·mol−1
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone; sometimes abbreviated as 3α,5β-THP), also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone.[1] It is a positive allosteric modulator of the GABAA receptor,[1] as well as a negative allosteric modulator of the glycine receptor,[2] and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects.[1][3][2] It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.[2][4]

See also

References

  1. 1.0 1.1 1.2 Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  2. 2.0 2.1 2.2 Jürgen Schüttler; Helmut Schwilden (8 January 2008). Modern Anesthetics. Springer Science & Business Media. pp. 278–. ISBN 978-3-540-74806-9.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  4. Norman Calvey; Norton Williams (21 January 2009). Principles and Practice of Pharmacology for Anaesthetists. John Wiley & Sons. pp. 110–. ISBN 978-1-4051-9484-6.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>