Ensaculin

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Ensaculin
Ensaculin.png
Systematic (IUPAC) name
7-methoxy-6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-3,4-dimethylchromen-2-one
Pharmacokinetic data
Biological half-life 13.7 hours
Identifiers
CAS Number 155773-59-4 YesY
ATC code none
PubChem CID: 208923
ChemSpider 181019 N
UNII 869PGR00AT N
ChEMBL CHEMBL1963107 N
Chemical data
Formula C26H32N2O5
Molecular mass 452.543
  • O=C/4Oc3cc(OC)c(OCCCN2CCN(c1ccccc1OC)CC2)cc3\C(=C\4C)C
  • InChI=1S/C26H32N2O5/c1-18-19(2)26(29)33-23-17-24(31-4)25(16-20(18)23)32-15-7-10-27-11-13-28(14-12-27)21-8-5-6-9-22(21)30-3/h5-6,8-9,16-17H,7,10-15H2,1-4H3 N
  • Key:FQELZLMTAPJJOL-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist.[1][2] Animal studies have shown promising nootropic effects,[3][4] although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure).[5]

References

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