Epstein–Barr virus small nucleolar RNA 1
| Human herpesvirus 1 small nucleolar RNA | |
|---|---|
| 220px | |
| Sequence concservation of v-snoRNA1 | |
| Identifiers | |
| Symbol | v-snoRNA1 |
| Rfam | RF01516 |
| Other data | |
| RNA type | snoRNA |
V-snoRNA1 is a box CD-snoRNA[clarification needed] identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)).[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.[2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR[clarification needed] of viral DNA polymerase mRNA.[1]
