Esreboxetine
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Systematic (IUPAC) name | |
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(2S)-2-[(S)-(2-ethoxyphenoxy)phenylmethyl]morpholine
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Clinical data | |
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Routes of administration |
Oral |
Identifiers | |
CAS Number | 98819-76-2 Y |
ATC code | none |
PubChem | CID: 65856 |
IUPHAR/BPS | 4808 |
ChemSpider | 59268 N |
UNII | L8S50ZY490 Y |
KEGG | D09340 Y |
Chemical data | |
Formula | C19H23NO3 |
Molecular mass | 313.391 g/mol |
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NY (what is this?) (verify) |
Esreboxetine is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued.[1][2][3][4] It is the (+)-(S,S)-enantiomer of reboxetine and is even more selective in comparison.[1][5]
However, recently it has been shown that esreboxetine could be effective in fibromyalgia patients.[6]
See also
References
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- ↑ Arnold, L. M., Hirsch, I., Sanders, P., Ellis, A. and Hughes, B. (2012), Safety and efficacy of esreboxetine in patients with fibromyalgia: A fourteen-week, randomized, double-blind, placebo-controlled, multicenter clinical trial. Arthritis & Rheumatism, 64: 2387–2397. doi: 10.1002/art.34390
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Articles with changed InChI identifier
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Drugs not assigned an ATC code
- Norepinephrine reuptake inhibitors
- Morpholines
- Phenol ethers
- Enantiopure drugs
- Analgesic stubs