Extramedullary hematopoiesis
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File:Nucleated red blood cells - endometrial polyp - high mag.jpg
Micrograph showing nucleated red blood cells (bottom left of image), one of the elements necessary to call extramedullary hematopoiesis, in an endometrial polyp. H&E stain.
Extramedullary hematopoiesis refers to hematopoiesis occurring outside of the medulla of the bone.
In some cases, it may be physiologic. For example, during fetal development, hematopoiesis occurs at many different locations, such as the liver and spleen.[1]
However, it is more frequently associated with pathologic processes. For example, it can be caused by myelofibrosis,[2] after fibrotic changes within the bone marrow "crowd out" hematopoietic cells, causing them to migrate to other sites such as the liver and spleen.
It can sometimes be identified via computed tomography.[3]
See also
References
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External links
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