FOXD3

Forkhead box D3
PDB rendering based on 2hfh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2hdc, 2hfh
Identifiers
Symbols	FOXD3 ; AIS1; Genesis; HFH2; VAMAS2
External IDs	OMIM: 611539 MGI: 1347473 HomoloGene: 49239 GeneCards: FOXD3 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • nuclear chromatin • nucleus • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • in utero embryonic development • trophectodermal cell differentiation • embryonic placenta development • transcription, DNA-templated • anatomical structure morphogenesis • cell differentiation • somatic stem cell maintenance • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27022	15221
Ensembl	ENSG00000187140	ENSMUSG00000067261
UniProt	Q9UJU5	Q61060
RefSeq (mRNA)	NM_012183	NM_010425
RefSeq (protein)	NP_036315	NP_034555
Location (UCSC)	Chr 1: 63.32 – 63.33 Mb	Chr 4: 99.66 – 99.66 Mb
PubMed search	[1]	[2]

Forkhead box D3 also known as FOXD3 is a forkhead protein that in humans is encoded by the FOXD3 gene.

Function

This gene belongs to the forkhead protein family of transcription factors which is characterized by a DNA-binding forkhead domain. FoxD3 functions as a transcriptional repressor and contains the C-terminal engrailed homology-1 motif (eh1), which provides an interactive surface with a transcriptional co-repressor Grg4 (Groucho-related gene-4).

Clinical significance

Mutations in this gene cause vitiligo.