Fasoracetam

Fasoracetam

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Names
IUPAC name (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one
Identifiers
CAS Number	110958-19-5 Y
ChEMBL	ChEMBL2106179
ChemSpider	171980 Y
Jmol 3D model	Interactive image Interactive image
KEGG	C13311 Y
PubChem	198695
InChI InChI=1S/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1 Y Key: GOWRRBABHQUJMX-MRVPVSSYSA-N Y InChI=1/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1 Key: GOWRRBABHQUJMX-MRVPVSSYBL
SMILES C1CCN(CC1)C(=O)C2CCC(=O)N2 O=C(N1CCCCC1)[C@@H]2NC(=O)CC2
Properties
Chemical formula	C10H16N2O2
Molar mass	196.246 g/mol
Pharmacology
Routes of administration	Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Fasoracetam (NS-105, 5-oxo-D-prolinepiperidinamide monohydrate) is a research chemical of the racetam family.

Effects

Fasoracetam appears to act as a GABA_B receptor antagonist. It has been shown to block memory disruptions caused by Baclofen, a GABA B agonist. Fasoracetam upregulates GABA B receptors after repeat dosing.

Fasoracetam may act as a mGluR agonist and research into the efficacy for treating ADHD and cognitive impairment is currently being conducted.

Similar to Coluracetam, Fasoracetam enhances high affinity choline reuptake (HACU).