File:ΔFosB accumulation.svg
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Summary
The top graph depicts the acute expression/induction of various Fos family proteins in mesolimbic dopamine neurons following an acute/initial exposure to an addictive drug.
The bottom graph depicts the accumulating expression of phosphorylated ΔFosB isoforms in the D1-type medium spiny neurons of the nucleus accumbens following repeated overdose on an addictive drug every 12 hours (upticks in expression occur at half-day intervals).
This image was redrawn manually in inkscape and based upon the more-or-less identical graphs from either of these sources:
- Malenka RC, Nestler EJ, Hyman SE () Sydor A, Brown RY , ed. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.), McGraw-Hill Medical, p. 110 <a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" class="extiw" title="en:International Standard Book Number">ISBN</a>: <a href="//commons.wikimedia.org/wiki/Special:BookSources/9780071481274" title="Special:BookSources/9780071481274">9780071481274</a>. “Figure 4–27”
- Nestler EJ, Barrot M, Self DW (September 2001). "<a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680">DeltaFosB: a sustained molecular switch for addiction</a>". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11042–11046. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.191352698">10.1073/pnas.191352698</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11572966">11572966</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680">58680</a>. "<a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680/figure/F1">Figure 1</a>"
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:27, 3 January 2017 | | 400 × 440 (227 KB) | 127.0.0.1 (talk) | The top graph depicts the acute expression/induction of various Fos family proteins in mesolimbic dopamine neurons following an acute/initial exposure to an addictive drug. <p>The bottom graph depicts the accumulating expression of phosphorylated ΔFosB isoforms in the D1-type medium spiny neurons of the nucleus accumbens following repeated overdose on an addictive drug every 12 hours (upticks in expression occur at half-day intervals). </p> <p>This image was redrawn manually in inkscape and based upon the more-or-less identical graphs from either of these sources: </p> <ol> <li><cite class="book" style="font-style:normal">Malenka RC, Nestler EJ, Hyman SE (<span style="white-space:nowrap"><time class="dtstart" datetime="2009">2009</time></span>) Sydor A, Brown RY , ed. <i> Molecular Neuropharmacology: A Foundation for Clinical Neuroscience</i> (2nd ed.), McGraw-Hill Medical, p. 110 <small><a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" class="extiw" title="en:International Standard Book Number">ISBN</a>: <a href="//commons.wikimedia.org/wiki/Special:BookSources/9780071481274" title="Special:BookSources/9780071481274">9780071481274</a>. </small> <span class="language">“Figure 4–27”</span></cite></li> <li><cite style="font-style:normal">Nestler EJ, Barrot M, Self DW (September 2001). "<a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680">DeltaFosB: a sustained molecular switch for addiction</a>". <i>Proc. Natl. Acad. Sci. U.S.A.</i> <b>98</b> (20): 11042–11046. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.191352698">10.1073/pnas.191352698</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11572966">11572966</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680">58680</a>. "<a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680/figure/F1">Figure 1</a>"</cite></li> </ol> |
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