File:DHFR methotrexate inhibitor.svg
Summary
An enzyme binding site that would normally bind substrate can alternatively bind a <a href="//commons.wikimedia.org/w/index.php?title=Competitive_inhibitor&action=edit&redlink=1" class="new" title="Competitive inhibitor (page does not exist)">competitive inhibitor</a>, preventing substrate access. <a href="//commons.wikimedia.org/w/index.php?title=Dihydrofolate_reductase&action=edit&redlink=1" class="new" title="Dihydrofolate reductase (page does not exist)">Dihydrofolate reductase</a> is inhibited by <a href="//commons.wikimedia.org/w/index.php?title=Methotrexate&action=edit&redlink=1" class="new" title="Methotrexate (page does not exist)">methotrexate</a> which prevents binding of its substrate, <a href="//commons.wikimedia.org/wiki/Folic_acid" class="mw-redirect" title="Folic acid">folic acid</a>. Binding site in blue, inhibitor in green, and substrate in black. (<a href="//commons.wikimedia.org/w/index.php?title=Protein_Data_Bank&action=edit&redlink=1" class="new" title="Protein Data Bank (page does not exist)">PDB</a>: <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4QI9">4QI9</a>)
Licensing
Lua error in package.lua at line 80: module 'strict' not found.
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:21, 7 January 2017 | | 1,800 × 1,728 (310 KB) | 127.0.0.1 (talk) | An enzyme binding site that would normally bind substrate can alternatively bind a <a href="//commons.wikimedia.org/w/index.php?title=Competitive_inhibitor&action=edit&redlink=1" class="new" title="Competitive inhibitor (page does not exist)">competitive inhibitor</a>, preventing substrate access. <a href="//commons.wikimedia.org/w/index.php?title=Dihydrofolate_reductase&action=edit&redlink=1" class="new" title="Dihydrofolate reductase (page does not exist)">Dihydrofolate reductase</a> is inhibited by <a href="//commons.wikimedia.org/w/index.php?title=Methotrexate&action=edit&redlink=1" class="new" title="Methotrexate (page does not exist)">methotrexate</a> which prevents binding of its substrate, <a href="//commons.wikimedia.org/wiki/Folic_acid" class="mw-redirect" title="Folic acid">folic acid</a>. Binding site in blue, inhibitor in green, and substrate in black. (<span class="plainlinks"><a href="//commons.wikimedia.org/w/index.php?title=Protein_Data_Bank&action=edit&redlink=1" class="new" title="Protein Data Bank (page does not exist)">PDB</a>: <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4QI9">4QI9</a></span>) |
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