File:Steroidogenesis.svg

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current08:57, 3 January 2017Thumbnail for version as of 08:57, 3 January 20171,245 × 1,105 (133 KB)127.0.0.1 (talk)Enzymes, their cellular location, substrates and products in human <a href="https://en.wikipedia.org/wiki/steroidogenesis" class="extiw" title="en:steroidogenesis">steroidogenesis</a>. <p>Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. </p> <p>White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see <a href="https://en.wikipedia.org/wiki/structural_formula" class="extiw" title="wikipedia:structural formula">Wikipedia:structural formula</a>. </p> <p>HSD: Hydroxysteroid dehydrogenase </p> <p><b>References:</b> </p> <ul> <li> <cite class="book" style="font-style:normal">Boron WF, Boulpaep EL (<span style="white-space:nowrap"><time class="dtstart" datetime="2003">2003</time></span>) <i> Medical Physiology: A Cellular And Molecular Approach</i>, Elsevier/Saunders, pp. page 1,300 <small><a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" class="extiw" title="en:International Standard Book Number">ISBN</a>: <a href="//commons.wikimedia.org/wiki/Special:BookSources/1-4160-2328-3" title="Special:BookSources/1-4160-2328-3">1-4160-2328-3</a>. </small></cite> </li> <li> For the absence of conversion of corticosterone to cortisol: <a rel="nofollow" class="external text" href="http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140">Steroid hormone biosynthesis Reference pathway (KO)</a>. <i>KEGG: Kyoto Encyclopedia of Genes and Genomes</i>. Kyoto University Bioinformatics Center. (<span class="mw-formatted-date" title="2013-11-01">1 November 2013</span>).</li> </ul> <dl><dd>There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.</dd></dl> <p><b>Further reading:</b> </p> <ul> <li> <cite style="font-style:normal">Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". <i>The Journal of Steroid Biochemistry and Molecular Biology</i> <b>43</b> (8): 779–804. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/0960-0760(92)90307-5">10.1016/0960-0760(92)90307-5</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/22217824">22217824</a>.</cite> </li> <li> <cite style="font-style:normal">Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". <i>Endocrine Reviews</i> <b>25</b> (6): 947–70. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210/er.2003-0030">10.1210/er.2003-0030</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15583024">15583024</a>.</cite> </li> </ul> <p><b>See also:</b> </p> <ul><li><a href="https://en.wikiversity.org/wiki/Diagram_of_the_pathways_of_human_steroidogenesis" class="extiw" title="wikiversity:Diagram of the pathways of human steroidogenesis">Wikiversity:Diagram of the pathways of human steroidogenesis</a></li></ul>
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