Forkhead box L2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Forkhead box protein L2 is a protein that in humans is encoded by the FOXL2 gene.[1][2]
Contents
Function
FOXL2 is a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function.[2]
Clinical significance
This protein is involved in sex determination. Female missing the FOXL2 gene appear male. FOXL2 knockout in mature mouse ovaries cause them to develop into testes, however oocytes are still formed.[3]
Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.[2]
See also
References
Further reading
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External links
- FOXL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GeneReviews/NCBI/NIH/UW entry on Blepharophimosis, Ptosis, and Epicanthus Inversus
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