KCNJ5
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein-activated inward rectifier potassium channel 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.[1][2]
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.[2]
Mutations in KCNJ5/Kir3.4 cause Andersen-Tawil syndrome .[3]
Interactions
KCNJ5 has been shown to interact with KCNJ3.[4][5]
See also
References
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Further reading
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External links
- KCNJ5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
