GR-89696

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GR-89696
GR-89696 structure.png
Systematic (IUPAC) name
methyl 4-[2-(3,4-dichlorophenyl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate
Identifiers
CAS Number 126766-32-3 YesY
PubChem CID: 3505
IUPHAR/BPS 1649
ChEMBL CHEMBL277863 N
Chemical data
Formula C19H25Cl2N3O3
Molecular mass 414.325 g/mol
  • Clc1ccc(cc1Cl)CC(=O)N2CCN(C(=O)OC)CC2CN3CCCC3
 NYesY (what is this?)  (verify)

GR-89696 is a drug which acts as a highly selective κ-opioid agonist.[1] It shows selective effects in different animal models and it is thought it may be a subtype-selective agonist for the κ2 subtype.[2][3][4] Recent studies have suggested that GR-89696 and related κ2-selective agonists may be useful for preventing the itching which is a common side effect of conventional opioid analgesic drugs, without the additional side effects of non-selective kappa agonists.[5]

References

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