Growth differentiation factor-9
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Growth/differentiation factor 9 is a protein that in humans is encoded by the GDF9 gene.[1][2]
Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily.[2]
GDF9 plays an important role in the development of primary follicles in the ovary.[3] It has a critical role in granulosa cell and theca cell growth, as well as in differentiation and maturation of the oocyte.[4][5]
GDF9 has been connected to differences in ovulation rate[6][7] and in premature cessation of ovary function,[8] therefore has a significant role in fertility.
The cell surface receptor through which GDF9 generates a signal is the bone morphogenetic protein type II receptor (BMPR2).[9][10]
References
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Further reading
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External links
- growth differentiation factor 9 at the US National Library of Medicine Medical Subject Headings (MeSH)
