HCN4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.[1][2][3][4]
There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart.[5] Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene.[6][7] The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.[8][9][10][11]
Interactions
HCN4 has been shown to interact with HCN2.[12]
See also
References
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Further reading
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External links
- GeneReviews/NIH/NCBI/UW entry on Brugada syndrome
- HCN4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- HCN4 human gene location in the UCSC Genome Browser.
- HCN4 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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