HLA-DR15
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major histocompatibility complex, class II, DR15
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| Haplotypes groups | DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507 |
| Structure (See HLA-DR) | |
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers |
beta 1 *1501 to *1505 *1507
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| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1501 |
| EBI-HLA | DRB1*1502 |
| EBI-HLA | DRB1*1503 |
| EBI-HLA | DRB1*1504 |
| EBI-HLA | DRB1*1505 |
| EBI-HLA | DRB1*1507 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Contents
Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 1501 | 76 | 23 | 6428 | |
| 1502 | 77 | 16 | 676 | |
| 1503 | 81 | 13 | 286 | |
| 1504 | >50 | 1 | ||
| 1505 | >25 | 2 | ||
| 1507 | >50 | 1 |
Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.
Alleles
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Disease associations
DR15 is positively associated Goodpasture syndrome,[2] early age onset multiple sclerosis,[3] pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7] and a predisposition for postmenopausal osteoporosis.[8]
DRB1*1501 is positively associated with Goodpasture syndrome,[9][10] juvenile rheumatoid arthritis,[11] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] systemic lupus erythematosus,[14] cervical cancer (human papillomavirus infection),[15] and Sjogren's syndrome associated with systemic lupus erythematosus.[16]
DRB1*1502 is associated with systemic lupus erythematosus,[17] systemic sclerosis (SSc) & anti-topoisomerase antibodies.[18]
DRB1*1503 is associated with Chaga's cardiomyopathy,[19] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] cervical cancer (human papillomavirus infection).[20]
Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[20]
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[17]
Genetic Linkage
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DR15 Haplotypes
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| Serotypes | DRA | DRB1 | DRB5 |
|---|---|---|---|
| DR15(2)-DR51 | *0101 | *1501 | *0101 |
| *0101 | *1502 | *0101 | |
| *0101 | *1503 | *0101 | |
| *0101 | *1504 | *0101 | |
| *0101 | *1505 | *0101 | |
| *0101 | *1507 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR15(2)-DQ6(6.2, 1) | *0102 | *0602 | *1501 |
| DR15(2)-DQ6(6.1, 1) | *0103 | *0601 | *1502 |
| HLA-A | HLA-B | DRB1 | |
| A3-Cw7-B7-DR15(2) | *0301 | *0702 | *1501 |
| A1-B51-DR15(2) | *0101 | *5101 | *1502 |
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
References
- ↑ derived from IMGT/HLA
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