HU-336

HU-336

Systematic (IUPAC) name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-1H-benzo[c]chromene-1,4(6H)-dione
Identifiers
PubChem	CID: 11370880
ChemSpider	9545797 Y
Chemical data
Formula	C21H28O3
Molecular mass	328.445 g/mol
SMILES O=C\2C=1OC([C@H]3[C@H](C=1C(=O)/C=C/2CCCCC)C/C(=C\C3)C)(C)C
InChI InChI=1S/C21H28O3/c1-5-6-7-8-14-12-17(22)18-15-11-13(2)9-10-16(15)21(3,4)24-20(18)19(14)23/h9,12,15-16H,5-8,10-11H2,1-4H3/t15-,16-/m1/s1 Y Key:GOZGLSHDDOJPJS-HZPDHXFCSA-N Y
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HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of pro- and antiangiogenic cytokines and their receptors. HU-336 is highly effective against tumor xenografts in nude mice.

See also

• HU-210
• HU-331
• HU-345