Haplogroup V (mtDNA)

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Haplogroup V
Possible time of origin 9800 YBP [1]
Possible place of origin Near East
Ancestor HV0a
Descendants V1, V2, V3, V4, V5, V6, V7, V8, V9
Defining mutations 4580[2]

Haplogroup V is a human mitochondrial DNA (mtDNA) haplogroup. The clade is believed to have originated around 9,800 years ago in the Near East.

Origin

Haplogroup V derives from the HV0a subclade of haplogroup HV. In 1998 it was argued that V spread over Europe from an Ice Age refuge in Iberia.[3] However more recent estimates of the date of V would place it in the Neolithic.[1]

Distribution

Haplogroup V is a relatively rare mtDNA haplogroup, occurring in around 4% of native Europeans.[4] Its highest concentration is among the Saami people of northern Scandinavia (~59%). It has been found at a frequency of approximately 10% among the Maris of the Volga-Ural region, leading to the suggestion that this region might be the source of the V among the Saami.[5][6] Additionally, haplogroup V has been observed at higher than average levels among Cantabrian people (15%) of northern Iberia,[7] and at a lower percentage among the adjacent Basque (10.4%).[8]

Haplogroup V is also found in parts of Northwest Africa. It is mainly concentrated among the Tuareg inhabiting the Gorom-Gorom area in Burkina Faso (21%),[9] Sahrawi in the Western Sahara (17.9%),[10] and Berbers of Matmata, Tunisia (16.3%).[11] The rare V7a subclade occurs among Algerians in Oran (1.08%) and Reguibate Sahrawi (1.85%).[12]

Ancient DNA

MtDNA haplogroup V has been reported in Neolithic remains of the Linear Pottery culture at Halberstadt, Germany c. 5000 BC[13] and Derenburg Meerenstieg, Germany c. 4910 BC.[14] Haplogroup V7 was found in representative Maykop culture samples in the excavations conducted by Alexei Rezepkin.[15] Haplogroup V has been detected in representatives Trypil'ska and Unetice culture.[16][17]

Haplogroup V has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[18]

Tree

This phylogenetic tree of haplogroup V subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.

  • HV0a
    • V
      • V1
        • V1a
          • V1a1
          • V1a2
      • V2
        • V2a
          • V2a1
            • V2a1a
        • V2b
          • V2b1
      • V3
      • V4
      • V5
      • V6
      • V7
        • V7a
      • V8
      • V9
        • V9a
      • V10
      • V11
      • V12
      • V14
      • V15
      • V16
      • V17
      • V18
      • V23
      • V24
      • V25
      • V26
      • V27
      • V28

See also

Evolutionary tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M   N  
CZ D E G Q   O A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References

  1. 1.0 1.1 Behar DM, et al. (2012). "A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root". The American Journal of Human Genetics. 90: 675–684. doi:10.1016/j.ajhg.2012.03.002. PMC 3322232. PMID 22482806.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. 2.0 2.1 van Oven M, Kayser M (Feb 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386-94. doi:10.1002/humu.20921. PMID 18853457.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Torroni A, et al. (1998). "mtDNA Analysis Reveals a Major Late Paleolithic Population Expansion from Southwestern to Northeastern Europe". American Journal of Human Genetics. 62: 1137–1152. doi:10.1086/301822. PMC 1377079. PMID 9545392.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Bryan Sykes (2001). The Seven Daughters of Eve. London; New York: Bantam Press. ISBN 0393020185.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Ingman M, Gyllensten U (2007). "A recent genetic link between Sami and the Volga-Ural region of Russia". European Journal of Human Genetics. 15: 115–120. doi:10.1038/sj.ejhg.5201712. PMID 16985502.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  6. Tambets K, Rootsi S, Kivisild T, Help H, Serk P, et al. (2004). "The Western and Eastern Roots of the Saami—the Story of Genetic "Outliers" Told by Mitochondrial DNA and Y Chromosomes". American Journal of Human Genetics. 74: 661–682. doi:10.1086/383203. PMC 1181943. PMID 15024688.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  7. Maca-Meyer N, Sánchez-Velasco P, Flores C, Larruga JM, González AM, Oterino A, Leyva-Cobián F (Jul 2003). "Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain)" (PDF). Annals of Human Genetics. 67 (Pt 4): 329–39. doi:10.1046/j.1469-1809.2003.00045.x. PMID 12914567.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  8. Soares P, Ermini L, Thomson N, Mormina M, Rito T, Röhl A, Salas A, Oppenheimer S, Macaulay V, Richards MB (2009). "Supplemental Data Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics. 84 (6): 82–93.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  9. Luísa Pereira; Viktor Černý; María Cerezo; Nuno M Silva; Martin Hájek; Alžběta Vašíková; Martina Kujanová; Radim Brdička; Antonio Salas (17 March 2010). "Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel". European Journal of Human Genetics. 18: 915–923. doi:10.1038/ejhg.2010.21. PMC 2987384. PMID 20234393. Retrieved 19 May 2016.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  10. S. Plaza; F. Calafell; A. Helal; N. Bouzerna; G. Lefranc; J. Bertranpetit; D. Comas (July 2003). "Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean". Annals of Human Genetics. 67 (4): 312–328. doi:10.1046/j.1469-1809.2003.00039.x. PMID 12914566. Retrieved 20 April 2016.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  11. Fadhlaoui-Zid K, Plaza S, Calafell F, Ben Amor M, Comas D, Bennamar El gaaied A (May 2004). "Mitochondrial DNA heterogeneity in Tunisian Berbers". Annals of Human Genetics. 68 (Pt 3): 222–33. doi:10.1046/j.1529-8817.2004.00096.x. PMID 15180702.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  12. Asmahan Bekada; Lara R. Arauna; Tahria Deba; Francesc Calafell; Soraya Benhamamouch; David Comas (September 24, 2015). "Genetic Heterogeneity in Algerian Human Populations". PLoS ONE. 10 (9): e0138453. doi:10.1371/journal.pone.0138453. PMC 4581715. PMID 26402429. Retrieved 8 May 2016.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>; S5 Table
  13. W. Haak et al., Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites, Science, vol. 310, no. 5750 (2005), pp. 1016-1018.
  14. W. Haak, et al., Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities, PloS Biology, vol. 8, no.11 (November 2010), e1000536.
  15. A. V. Nedoluzhko, E. S. Boulygina, A. S. Sokolov, S. V. Tsygankova, N. M. Gruzdeva, A. D. Rezepkin, E. B. Prokhortchouk. Analysis of the Mitochondrial Genome of a Novosvobodnaya Culture Representative using Next-Generation Sequencing and Its Relation to the Funnel Beaker Culture
  16. A. G. Nikitin et al. (2010) Comprehensive site chronology and ancient Mitochondrial DNA analysis from Verteba cave – a trypillian culture site of eneolithic Ukraine
  17. Unetice Culture (c. 2300-1600 BCE)
  18. Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González. "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14: 109. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141. Retrieved 30 January 2016.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  19. http://phylotree.org/tree/R0.htm

External links