ITPR2

Inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
Symbols	ITPR2 ; ANHD; CFAP48; INSP3R2; IP3R2
External IDs	OMIM: 600144 MGI: 99418 HomoloGene: 37593 IUPHAR: 744 ChEMBL: 2512 GeneCards: ITPR2 Gene
Gene ontology Molecular function • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • calcium ion transmembrane transporter activity • phosphatidylinositol binding Cellular component • endoplasmic reticulum membrane • plasma membrane • cell cortex • membrane • integral component of membrane • platelet dense tubular network membrane • sarcoplasmic reticulum membrane • receptor complex Biological process • response to hypoxia • stimulatory C-type lectin receptor signaling pathway • energy reserve metabolic process • transport • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • fibroblast growth factor receptor signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • small molecule metabolic process • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • inositol phosphate-mediated signaling • regulation of insulin secretion • calcium ion transmembrane transport • cellular response to cAMP • cellular response to ethanol Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3709	16439
Ensembl	ENSG00000123104	ENSMUSG00000030287
UniProt	Q14571	Q9Z329
RefSeq (mRNA)	NM_002223	NM_010586
RefSeq (protein)	NP_002214	NP_034716
Location (UCSC)	Chr 12: 26.34 – 26.83 Mb	Chr 6: 146.11 – 146.5 Mb
PubMed search	[1]	[2]

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

See also

• Inositol trisphosphate receptor

External links

• ITPR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)