Indeloxazine

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Indeloxazine
Indeloxazine.svg
Systematic (IUPAC) name
2-(3H-Inden-4-yloxymethyl)morpholine
Clinical data
Legal status
  • Discontinued
Identifiers
CAS Number 60929-23-9 YesY
ATC code none
PubChem CID: 3704
ChemSpider 3576 YesY
UNII 834M09R1KM YesY
KEGG D08077 YesY
Synonyms CI-874, YM-08054
Chemical data
Formula C14H17NO2
Molecular mass 231.290 g/mol
  • O(c1cccc2\C=C/Cc12)CC3OCCNC3
  • InChI=1S/C14H17NO2/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12/h1-4,6,12,15H,5,7-10H2 YesY
  • Key:MADRVGBADLFHMO-UHFFFAOYSA-N YesY
  (verify)

Indeloxazine (INN) (Elen, Noin), or indeloxazine hydrochloride (USAN, JAN), is an antidepressant and cerebral activator[1][2] that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition.[3][4] It was marketed from 1988[4] to 1998, when it was removed from the market reportedly for lack of effectiveness.[5]

Indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist.[6][7] It has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor via its action as a serotonin releasing agent.[8][9][10] The drug has been found to possess nootropic,[11][12] neuroprotective,[13][14][15][16] anticonvulsant,[17] and antidepressant-like effects in animal models.[1][6]

See also

References

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  6. ↑ 6.0 6.1 Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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