Amine N-methyltransferase
| amine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
indolethylamine N-methyltransferase (with slight variation on CPK coloration) – See PDB 2A14
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| Identifiers | |||||||||
| EC number | 2.1.1.49 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an amine N-methyltransferase (EC 2.1.1.49) is an enzyme that is ubiquitously present in non-neural tissues and that catalyzes the N-methylation of tryptamine and structurally related compounds.[1]
The chemical reaction taking place is:
- S-adenosyl-L-methionine + an amine
S-adenosyl-L-homocysteine + a methylated amine
Thus, the two substrates of this enzyme are S-adenosyl methionine and amine, whereas its two products are S-adenosylhomocysteine and methylated amine. In the case of tryptamine and serotonin these then become the dimethylated indolethylamines dimethyltryptamine (DMT) and bufotenine.[2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:amine N-methyltransferase. Other names in common use include nicotine N-methyltransferase, tryptamine N-methyltransferase, indolethylamine N-methyltransferase, and arylamine N-methyltransferase. This enzyme participates in tryptophan metabolism.
A wide range of primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.[1]
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2A14.
See also
References
- ↑ 1.0 1.1 tryptamine N-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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External links
- EC 2.1.1.49
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