Interferon regulatory factors
| Interferon regulatory factor transcription factor | |||||||||
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| File:PDB 1irf EBI.jpg
interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
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| Identifiers | |||||||||
| Symbol | IRF | ||||||||
| Pfam | PF00605 | ||||||||
| InterPro | IPR001346 | ||||||||
| SCOP | 1if1 | ||||||||
| SUPERFAMILY | 1if1 | ||||||||
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Interferon regulatory factors are proteins which regulate transcription of interferons (see regulation of gene expression).[1]
They are used in the JAK-STAT signaling pathway.[2]
Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes.[3] The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.[3]
Contents
Genes
See also
References
External links
- Interferon regulatory factors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the public domain Pfam and InterPro IPR001346
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