Intraductal papilloma

Intraductal papilloma
File:Intraductal papilloma histopathology (3) p63.JPG Histopathology of intraductal papilloma of the breast by excisional biopsy. Immunostaining for p63 protein.
Classification and external resources
Specialty
ICD-O	M8503/0
DiseasesDB	31244
MedlinePlus	001238
Patient UK	Intraductal papilloma
MeSH	D018300

Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in humans.

Two types of intraductal papillomas are generally distinguished. The central type develops near the nipple. They are usually solitary and often arise in the period nearing menopause. On the other hand, the peripheral type are often multiple papillomas arising at the peripheral breasts, and are usually found in younger women. The peripheral type are associated with a higher risk of malignancy.

They are the most common cause of bloody nipple discharge in women age 20-40 and generally do not show up on mammography due to their small size, so the next step in treatment would be a galactogram to guide the subsequent biopsy.

The masses are often too small to be palpated or felt. A galactogram is therefore necessary to rule out the lesion.

Excision is sometimes performed. Microdochectomy/microdochotomy (removal of a breast duct) is the treatment of choice.

Additional images

• Intraductal papilloma histopathology (1).jpg

  Histopathology of intraductal papilloma of the breast by excisional biopsy. Hematoxylin and eosin stain.

• Intraductal papilloma histopathology (2) smooth muscle actin.JPG

  Histopathology of intraductal papilloma of the breast by excisional biopsy. Immunostaining for alpha-smooth muscle actin.

• Ultrasound 12070I26 intraductal papilloma nevit.jpg
• Ultrasound 12070I33 intraductal papilloma nevit.jpg
• Ultrasound 12070I40 intraductal papilloma nevit.jpg
• Ultrasound 12070I6 intraductal papilloma nevit.jpg
• Ultrasound 12070I25 intraductal papilloma nevit.jpg
• Ultrasound 12070I12 intraductal papilloma nevit.jpg