Invasive lobular carcinoma
From Infogalactic: the planetary knowledge core
| Invasive lobular carcinoma | |
|---|---|
| File:Breast invasive lobular carcinoma (2).jpg
Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-O | M8520/3 |
| Patient UK | Invasive lobular carcinoma |
File:LobularBreastCancer.jpg
Lobular breast cancer. Single file cells and cell nests.
Invasive lobular carcinoma accounts for 5-10% of invasive breast cancer.[1][2]
The histologic patterns include:[3][4][5]
| Type | Prevalence | Description |
|---|---|---|
| Classical | 40% | round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern |
| Alveolar | 5% | Aggregates of classical-appearing cells |
| Solid | 10% | Sheets of classical-appearing cells with little intervening stroma |
| Tubulolobular | 5% | Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma) |
| Pleomorphic | Classical-appearing but with pleomorphic cells | |
| Mixed | 40% | No dominant pattern |
Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.[6]
Loss of E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.[7]
Treatment includes surgery and adjuvant therapy.
References
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- ↑ Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.
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