Iomazenil

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Iomazenil
Iomazenil structure.svg
Systematic (IUPAC) name
ethyl 7-iodanyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Identifiers
CAS Number 127985-21-1
Template:CAS (123I)
PubChem CID: 65959
ChemSpider 59362
UNII B851121553
ChEMBL CHEMBL2105020
Synonyms Ro 16-0154
Chemical data
Formula C15H14123IN3O3
Molecular mass 407.290 g/mol
  • CCOC(=O)c1c2n(cn1)-c3cccc(c3C(=O)N(C2)C)I
  • InChI=1S/C15H14IN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3/i16-4
  • Key:FRIZVHMAECRUBR-KIWWSDKQSA-N

Iomazenil (also known as Ro16-0154, INN, USAN; benzodine) is an antagonist and partial inverse agonist of benzodiazepine and a potential treatment for alcohol abuse. The compound was introduced in 1989 by pharmaceutical company Hoffmann-La Roche as an Iodine-123-labelled SPECT tracer for imaging benzodiazepine receptors (GABAA receptors) in the brain. Iomazenil is an analogue of flumazenil (Ro15-1788).[1]

Use in brain research

123I-labelled iomazenil can be used to image epileptic seizure foci as an alternative to 18F-fludeoxyglucose PET imaging.[2][3]

The effect of iomazenil of reducing levels of GABA in the brain was used by researchers to exacerbate symptoms in patients with schizophrenia in a laboratory study, supporting the theory that a GABA deficiency underlies that disease.[4]

Alcohol treatment

Researcher Deepak D'Souza and colleagues at Yale University and Veterans Affairs Connecticut Healthcare System are testing iomazenil as a potential treatment for drunkenness due to its ability to bind alcohol receptors in the brain.[5]

References

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External links