Irwin Rose

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Irvin Rose
Nobel2004chemistrylaurets-Rose.jpg
Irwin Rose, c. 2000
Born Irwin Allan Rose
(1926-07-16)July 16, 1926
Brooklyn, New York, U.S.
Died June 2, 2015(2015-06-02) (aged 88)
Deerfield, Massachusetts, U.S.
Nationality United States
Fields Biology
Institutions
Alma mater University of Chicago (BS, PhD)
Known for Ubiquitin-mediated protein degradation
Notable awards Nobel Prize in Chemistry (2004)
Spouse Zelda Budenstein[citation needed]
Children 4[citation needed]

Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.[1][2][3][4][5][6][7]

Education and early life

Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store.[8] Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago.[9]

Career and research

Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995.[10] He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry.[11] He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004.[10]

Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas,[12] the first to see Ubiquitin chains, Keith Wilkinson,[1] the one to first identify APF-1 as Ubiquitin, and Cecile Pickart,[13] a world class enzymologist in many parts of the Ub system.

Awards and honours

Rose was awarded the Nobel prize in 2004.[14][15][16]

Personal life

Rose was married to Zelda Budenstein and had four children.[citation needed] He died on June 2, 2015 at Deerfield, Massachusetts.[9][17]


References

  1. 1.0 1.1 Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
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  3. "Nobel Prize in Chemistry, 2004. Aaron Ciechanover, Avram Hershko and Irwin Rose", Indian J. Physiol. Pharmacol., 49 (1), p. 121, 2005, PMID 15881872<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Latonen, Leena; Laiho, Marikki (2004), "Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway", Duodecim; lääketieteellinen aikakauskirja, 120 (24), pp. 2868–71, PMID 15700582<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  6. Neefjes, J; Groothuis, T A M; Dantuma, N P (2004), "The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation", Nederlands tijdschrift voor geneeskunde (published Dec 25, 2004), 148 (52), pp. 2579–82, PMID 15646859<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  7. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  8. Nobelprize.org - Irwin Rose Autobiography
  9. 9.0 9.1 Chang, Kenneth (2 June 2015). "Irwin A. Rose, Nobel-Winning Biochemist, Dies at 88". New York Times. Retrieved 4 June 2015.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  10. 10.0 10.1 Weil, Martin (3 June 2015). "Irwin Rose, who shared 2004 Nobel Prize in chemistry, dies at 88". Washington Post. Retrieved 4 June 2015.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  11. "Selected Awards and Honors to Penn Faculty and Alumni: Nobel Prizes". University of Pennsylvania Website. Retrieved 4 June 2015.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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  14. Nobel citation
  15. Rose Nobel Prize lecture
  16. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  17. ABC News. "2004 Nobel Chemistry Winner Irwin Rose Dies at 88". ABC News.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>