Isothiazole
From Infogalactic: the planetary knowledge core
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| Identifiers | |||
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| 288-16-4 | |||
| ChEBI | CHEBI:35600  |
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| ChemSpider | 60838 |
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| Jmol 3D model | Interactive image | ||
| PubChem | 67515 | ||
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| Properties | |||
| C3H3NS | |||
| Molar mass | 85.12 g·mol−1 | ||
| Boiling point | 114 °C (237 °F; 387 K)[2] | ||
| Acidity (pKa) | -0.5 (of conjugate acid) [1] | ||
| Vapor pressure | {{{value}}} | ||
| Related compounds | |||
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Related compounds
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thiazole, isoxazole | ||
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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An isothiazole, or 1,2-thiazole, is a type of organic compound containing a five-membered aromatic ring that consists of three carbon atoms, one nitrogen atom, and one sulfur atom.[3] Isothiazole is a member of a class of compounds known as azoles. In contrast to the isomeric thiazole, the two heteroatoms are in adjacent positions.
The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.
References
- ↑ Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978).
- ↑ Isothiazoles, D. W. Brown and M. Sainsbury, page 513
- ↑ Heterocyclic Chemistry, 3rd Edition, J.A. Joule, K. Mills, and G.F. Smith, page 394
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