He helped found the Astronomical Society of London, and it was under his name as president of the society from 1831 to 1832 that a petition was successfully submitted to obtain a royal charter in 1831, whereupon it became the Royal Astronomical Society.
South and John Herschel jointly produced a catalogue of 380 double stars in 1824, reobserving many of the double stars that had been discovered by William Herschel. South then continued and observed another 458 double stars over the following year.
Starting around 1826, James South made plans for a new, larger telescope, an equatorially mounted achromatic refractor (a telescope with a lens) in a new observatory. He bought a 12-inch (actually about 11.8) aperture lens from Robert-Aglaé Cauchoix in Paris for about 1000 pounds, large enough to be the biggest achromatic object lens in the world at the time. The telescope for the lens was completed, but dismantled around 1838. The next largest refractor, was at the Markree Observatory, which successfully completed a 13.3 inch refractor (also a Cauchoix of Paris lens) in the 1830s on a Thomas Grubb mount.  The problem for James South's telescope was the equatorial mount.
South was involved in a notorious lawsuit brought against him by the instrument maker Edward Troughton over this equatorial-mount telescope which the latter had constructed for him, and which South considered defective. Troughton sued him for payment and won. South promptly demolished the telescope mount; the 12 inch lens, which had been purchased separately, was preserved and presented to the (Dublin) Dunsink Observatory in 1862.  The Observatory mounted it on a Grubb equatorial, where it survives to the present day. (See also Great refractors)
- National Portrait Gallery portrait
- Wikisource copy of a notice from 1823 concerning the star catalogue, published in Astronomische Nachrichten
- MNRAS 28 (1868) 69
- Title: The Observatory of the Late Sir James South Journal: Astronomical register, vol. 8, pp.196-199
- Agnes Mary Clerke (1898). . In Lee, Sidney (ed.). Dictionary of National Biography. 53. London: Smith, Elder & Co.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- Refracting Telescopes of the 19th Century
- History of Cauchoix objectives
- The South Telescope of Dunsink Observatory, Authors: Wayman, P. A., Journal: Irish Astronomical Journal, vol. 8(8), p. 274
- Google Books 2010
- Kensington Observatory (Campden Hill) (Google Books 2010)
- Monthly Notices of the Royal Astronomical Society, Volume 28, By Royal Astronomical Society: Sir James South, Page 69-72