Jane Clarke (scientist)

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For other people called Jane Clarke, see Jane Clarke.
Jane Clarke
File:Professor Jane Clarke FMedSci FRS.jpg
Jane Clarke in 2015, portrait via the Royal Society
Born Jane Morgan[1]
(1950-09-10) 10 September 1950 (age 73)[1]
London
Fields <templatestyles src="Plainlist/styles.css"/>
Institutions <templatestyles src="Plainlist/styles.css"/>
Alma mater <templatestyles src="Plainlist/styles.css"/>
Thesis Studies of disulphide mutants of barnase (1993)
Doctoral advisor Alan Fersht[2]
Notable students <templatestyles src="Plainlist/styles.css"/>
Notable awards <templatestyles src="Plainlist/styles.css"/>
Spouse Christopher Clarke (m. 1973)[1]
Children one son, one daughter[1]
Website
www-clarke.ch.cam.ac.uk

Jane Clarke, FRS, FRSC, FMedSci, , , , , , , , , , , , , , , , , (née Morgan; born 10 September 1950) is Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow[24] in the Department of Chemistry at the University of Cambridge and a Fellow of Trinity Hall, Cambridge.[25][26]

Education and Career

Clarke was educated at the University of York where she graduated with a first class honours degree in Biochemistry in 1972.[1] She went on to study for a Postgraduate Certificate in Education (PGCE) at the University of Cambridge in 1973.[1] Clarke was a science teacher in several secondary schools, and a Head of Science at Northumberland Park School, Tottenham from 1973 to 1986.

She returned to research, gaining a Master of Science degree in Applied Biology in 1990 from the Georgia Institute of Technology and a PhD in 1993 for investigations of Bacterial Ribonuclease (Barnase) from the University of Cambridge supervised by Alan Fersht.[2][27][28]

Clarke was appointed a Wellcome Trust Senior Research Fellow in 2001, a Professor of Molecular Biophysics in 2009 and a Fellow of Trinity Hall, Cambridge in 2010.[1]

Research

Clarke's research investigates protein folding,[29] in particular:

  1. Studies of Structurally Related Proteins
  2. Multidomain Proteins: Effects of Sequence on Folding and Misfolding
  3. Folding and Assembly: Intrinsically disordered proteins

Clarke's research has been funded by the Wellcome Trust,[24] Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council (BBSRC)[30] and has been published in leading peer reviewed scientific journals including Biochemistry,[28] Structure,[31] the Journal of Biological Chemistry, the Biophysical Journal,[18][19][32][33][34][35][36] Nature,[37] Science,[16] PNAS,[38] the Journal of the American Chemical Society,[20][39][40][41] Current Opinion Structural Biology [8][42][43][44][45] and the Journal of Molecular Biology.[46][47]

Awards and honours

In 2010, Clarke was awarded the US Genomics award from the Biophysical Society.[48] Clarke was also elected a Fellow of the Royal Society of Chemistry and a Fellow of the Academy of Medical Sciences (FMedSci) in 2013.[1] Her nomination for the Academy of Medical Sciences reads: <templatestyles src="Template:Blockquote/styles.css" />

Jane Clarke is a distinguished biophysical chemist at the University of Cambridge. She is recognised internationally for her multidisciplinary studies that have advanced the understanding of protein folding and misfolding. She pioneered the application of protein engineering techniques together with single molecule force spectroscopy and simulations to investigate the effect of force on proteins. For this she was awarded the Biophysical Society U.S Genomics Award for Outstanding Investigator in the field of Single Molecule Biology in 2010; at the time, the only non-US and still the only female recipient of this prestigious award.[49]

Clarke was elected a Fellow of the Royal Society (FRS) in 2015. Her certificate of election reads: <templatestyles src="Template:Blockquote/styles.css" />

Jane Clarke is distinguished for the rigorous physical chemistry approaches she has adapted and applied to understand protein folding and misfolding. Her fundamental studies revealed the presence of both parallel pathways and frustration in the energy landscape of apparently simple proteins. Most significantly, she has made very important advances in the study of multi-domain systems. From her discovery that aggregation and misfolding are determined by sequence similarity, through to her seminal studies combining force spectroscopy and protein engineering to elucidate mechanical unfolding energy landscapes, she has transformed our understanding of the evolution, folding and energetics of multidomain proteins.[50]

Personal life

Clarke married Christopher Clarke in 1973 and has one son and one daughter.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Lua error in package.lua at line 80: module 'strict' not found. (subscription required)
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ 12.0 12.1 12.2 Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  14. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  16. ↑ 16.0 16.1 Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ 18.0 18.1 Lua error in package.lua at line 80: module 'strict' not found.
  19. ↑ 19.0 19.1 Lua error in package.lua at line 80: module 'strict' not found.
  20. ↑ 20.0 20.1 Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  23. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ 24.0 24.1 Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ Jane Clarke's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  27. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  28. ↑ 28.0 28.1 Lua error in package.lua at line 80: module 'strict' not found.
  29. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  30. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  31. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  32. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  33. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  34. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  36. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  37. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  38. ↑ Lua error in package.lua at line 80: module 'strict' not found. open access publication - free to read
  39. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  40. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  41. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  42. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  44. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  45. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  46. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  47. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  48. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  49. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  50. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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